Who Gets AIHA?
Although it can occur in any breed at any age, genetic factors seem to influence susceptibility to autoimmunity.
This is supported by the high occurrence of AIHA in certain breeds. Breeds mentioned in literature I've read include Cocker Spaniels, Poodles, Old English Sheepdogs, Shetland Sheepdogs, Irish Setters, Lhasa Apsos, Shih Tzus, Dachshunds, German Shepherds, Springer Spaniels, Scottish Terriers and Vizslas.
Primary IMHA, AutoImmune Hemolytic Anemia, is most frequently seen in middle aged females. Obviously with secondary IMHA there would be no sex predilection.
It is interesting to note the correlation between the female sex and autoimmunity. The administration of androgens and/or antiestrogen has even been shown to prevent or diminish autoimmune reactions.
Also note that there are genetic defects within certain breeds that mimic AIHA but are quite different. These include Phosphofructokinase Deficiency in English Springer Spaniels & American Cocker Spaniels, and Pyruvate Kinase Deficiency which is seen in Beagles, Basenjis, Westies and Giant Schnauzers.
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